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DT-109 Ameliorates Nonalcoholic Steatohepatitis in Non-Human Primates

Pengxiang Qu, Oren Rom, Ke Li, Linying Jia, Xiaojing Gao, Zhipeng Liu, Shusi Ding, Mingming Zhao, Huiqing Wang, Shuangshuang Chen, Xuelian Xiong, Ying Zhao, Chao Xue, Yang Zhao, Chengshuang Chu, Bo Wen, Alexandra C. Finney, Zuowen Zheng, Wenbin Cao, Jinpeng Zhao, Liang Bai, Sihai Zhao, Duxin Sun, Rong Zeng, Jiandie Lin, Wanqing Liu, Lemin Zheng, Jifeng Zhang, Enqi Liu, and Y. Eugene Chen. Cell Metabolism. May 2, 2023, Volume 35, 1–16. 


Clopidogrel Resistance in a Murine Model of Diet-Induced Obesity Is Mediated by the Interleukin-1 Receptor and Overcome With DT-678

Sun Y, Venugopal J, Guo C, Fan Y, Li J, Gong Y, Chen YE, Zhang H, Eitzman, DT. Arterioscler Thromb Vasc Biol. 2020 Jun;40(6):1533-1542.


DT-678 inhibits platelet activation with lower tendency for bleeding compared to existing P2Y 12 antagonists

Lauver DA, Kuszynski DS, Christian BD, Bernard MP, Teuber JP, Markham BE, Chen YE, Zhang H. Pharmacol Res Perspect. 2019 Jul 25;7(4):e00509.


Significant Improvement of Antithrombotic Responses to Clopidogrel by Use of a Novel Conjugate as Revealed in an Arterial Model of Thrombosis

Zhang H, Lauver DA, Wang H, Sun D, Hollenberg PF, Chen YE, Osawa Y, Eitzman DT. J Pharmacol Exp Ther. 2016 Oct;359(1):11-7. 


CYP-independent inhibition of platelet aggregation in rabbits by a mixed disulfide conjugate of clopidogrel

Zhang H, Lauver DA, Hollenberg PF. . Thromb Haemost. 2014 Dec;112(6):1304-11.


Formation, reactivity, and antiplatelet activity of mixed disulfide conjugates of clopidogrel

Zhang H, Lauver DA, Lucchesi BR, Hollenberg PF. . Mol Pharmacol. 2013 Apr;83(4):848-56. 


Formation of the thiol conjugates and active metabolite of clopidogrel by human liver microsomes

Zhang H, Lau WC, Hollenberg PF. . Mol Pharmacol. 2012 Aug;82(2):302-9.


Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis

Rom O, Liu Y, Liu Z, Zhao Y, Wu J, Ghrayeb A, Villacorta L, Fan Y, Chang L, Wang L, Liu C, Yang D, Song J, Rech JC, Guo Y, Wang H, Zhao G, Liang W, Koike Y, Lu H, Koike T, Hayek T, Pennathur S, Xi C, Wen B, Sun D, Garcia-Barrio MT, Aviram M, Gottlieb E, Mor I, Liu W, Zhang J, Chen YE. Sci Transl Med. 2020 Dec 2;12(572):eaaz2841.


Emerging therapeutic potential of glycine in cardiometabolic diseases: dual benefits in lipid and glucose metabolism

Rom O, Villacorta L, Zhang J, Chen YE, Aviram M. Curr Opin Lipidol. 2018 Oct;29(5):428-432.


A tripeptide Diapin effectively lowers blood glucose levels in male type 2 diabetes mice by increasing blood levels of insulin and GLP-1

Zhang J, Xue C, Zhu T, Vivekanandan A, Pennathur S, Ma ZA, Chen YE. PLoS One. 2013 Dec 27;8(12):e83509.

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