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Publications
Tripeptide DT-109 (Gly-Gly-Leu) attenuates atherosclerosis and vascular calcification in nonhuman primates
Linying Jia, Pengxiang Qu, Yang Zhao, Liang Bai, Honghao Ren, Ao Cheng, Zeyao Ma, Cheng Ding, Yongjie Deng, Lingxuan Kong, Ying Zhao, Oren Rom, Yajie Chen, Naqash Alam, Wenbin Cao, Sixue Zhai, Zuowen Zheng, Zhi Hu, Lu Wang, Yabing Chen, Sihai Zhao, Jifeng Zhang, Jianglin Fan, Y. Eugene Chen & Enqi Liu, Signal Transduct Target Ther, 2025 Apr 7;10(1):122
The first in-human study to evaluate the antiplatelet properties of the clopidogrel conjugate DT-678 in acute coronary syndrome patients and healthy volunteers
Zhihao Liu, Shengcong Liu, Yanjun Gong, Xiying Chi, Ting Wang, Fangfang Fan, Chenxue Qu, Yaxin Lou, Long Zhang, Bin Zhang, Fan Yang, Momin Mohetaboer, Jie Wang, Lin Qiu, Linzi Miao, Yao Lu, Ran You, Pengkang He, Yuxi Li, Tieci Yi, Haoyu Weng, Yulong Xia, Chunyan Wang, Qiuping Shi, Zhi Wang, Yimeng Jiang, Yinjuan Li, Chunyu Han, Yu Wang, Xinghe Wang, Caixia Yang, Y. Eugene Chen, Daniel T. Eitzman, Haoming Zhang, Jianping L,
Br J Pharmacol, 2025 Jan;182(1):131-141.
DT-109 Ameliorates Nonalcoholic Steatohepatitis in Non-Human Primates
Pengxiang Qu, Oren Rom, Ke Li, Linying Jia, Xiaojing Gao, Zhipeng Liu, Shusi Ding, Mingming Zhao, Huiqing Wang, Shuangshuang Chen, Xuelian Xiong, Ying Zhao, Chao Xue, Yang Zhao, Chengshuang Chu, Bo Wen, Alexandra C. Finney, Zuowen Zheng, Wenbin Cao, Jinpeng Zhao, Liang Bai, Sihai Zhao, Duxin Sun, Rong Zeng, Jiandie Lin, Wanqing Liu, Lemin Zheng, Jifeng Zhang, Enqi Liu, and Y. Eugene Chen. Cell Metabolism. May 2, 2023, Volume 35, 1–16.
Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis
Rom O, Liu Y, Liu Z, Zhao Y, Wu J, Ghrayeb A, Villacorta L, Fan Y, Chang L, Wang L, Liu C, Yang D, Song J, Rech JC, Guo Y, Wang H, Zhao G, Liang W, Koike Y, Lu H, Koike T, Hayek T, Pennathur S, Xi C, Wen B, Sun D, Garcia-Barrio MT, Aviram M, Gottlieb E, Mor I, Liu W, Zhang J, Chen YE. Sci Transl Med. 2020 Dec 2;12(572):eaaz2841.
Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome
Oren Rom, Yuhao Liu, Zhipeng Liu, Ying Zhao,, Jianfeng Wu, Alia Ghrayeb, Luis Villacorta, Yanbo Fan, Lin Chang, Lu Wang, Cai Liu, Dongshan Yang, Jun Song, Jason C Rech, Yanhong Guo, Huilun Wang, Guizhen Zhao, Wenying Liang, Yui Koike, Haocheng Lu, Tomonari Koike, Tony Hayek, Subramaniam Pennathur, Chuanwu Xi, Bo Wen, Duxin Sun, Minerva T Garcia-Barrio, Michael Aviram, Eyal Gottlieb, Inbal Mor, Wanqing Liu, Jifeng Zhang, Y Eugene Chen, Sci Transl Med. 2020.
